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High Purity Pharmaceutical API saxagliptin BMS477118 Powder CAS 361442-04-8 CAS NO.361442-04-8
- FOB Price: USD: 8.20-8.80 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
A(1-10)KilogramA(10-100)Kilogram
- Product Details
Keywords
- 361442-04-8
- saxagliptin Powder
- saxagliptin BMS477118
Quick Details
- ProName: High Purity Pharmaceutical API saxagli...
- CasNo: 361442-04-8
- Molecular Formula: C18H25N3O2
- Appearance: Powder
- Application: Pharmaceutical API
- DeliveryTime: 3 days
- PackAge: As request
- Port: Shanghai
- ProductionCapacity: 1000 Metric Ton/Year
- Purity: 99%
- Storage: Cool and dry
- Transportation: As product request.
- LimitNum: 1 Kilogram
- Related Substances: saxagliptin
- Residue on Ignition: N/A
- Heavy Metal: N/A
- Valid Period: 2025
- Grade: Industrial Grade,Pharma Grade,Electron...
- Boiling Point: 548.7±35.0 °C at 760 mmHg
- Melting Point: 255-264oC
- Molecular Weigh: 315.4
- Density: 1.3±0.1 g/cm3
Superiority
1. A strong scientific research team .
2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products).
3. Rich export experience (with practical experience in exporting to more than 30 countries such as North America, Europe, Middle East, and Southeast Asia).
4. Professional pre-sales and after-sales services (customer first is the core belief of our sales team).
5. Ability to provide value-added services (we can provide a wealth of product solutions to help customers improve competitiveness and production.
6. Safe and fast delivery Most products have a large inventory, so the products can be sent fast after confirming payment, and the tracking number and packaging details will be notified as soon as possible; Large amount of our products are exported to many countries, such as Germany, Brazil, the United States, Spain, the United Kingdom, France, Canada, Mexico, Poland, Russia, Australia, Norway, Finland and so on, with more than 1000 kg per month. We have cooperative agents in these countries. Our customs clearance company will clear your package without customs problems.
7. Rich experience
We are a professional manufacturer of pharmaceutical chemical raw materials. We have focused on this field for many years, and our product is BP / USP / EP / enterprise standard. We guarantee all purity > 99%. High purity and good quality are one of the greatest secrets of our success; You can get the best quality and service from us
Details
Product name | saxagliptin |
CAS number | 361442-04-8 |
Purity | 99% |
Usages:
Pharmaceutical API
Saxagliptin(BMS477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.IC50 value: 26 nM [1]Target: DPP4in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and <250-fold, respectively, compared with DPP8 and DPP9) [2]. Saxagliptin reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion.in vivo: Saxagliptin is highly effective at eliciting marked dose-dependent enhancements in glucose clearance in the dose range 0.13-1.3 mg/kg in ob/ob mice relative to controls. Saxagliptin dose-dependently elevate plasma insulin significantly at 15 min post-oGTT, with concomitant improvement in the glucose clearance curves at 60 min post-oGTT
About Us:
Hebei Kunsui Technology Co., Ltd. specializes in exporting high quality Pharmaceutical raw materials, plant extract, pesticide raw materials and Chemical raw materials.
Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.
Packing & Shipping:
Packing&Delivery:
Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.
Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.
Shelf Life: 2 years if sealed and store away from direct sun light.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Delivery time: Around 3 workdays after your payment.
Payments:We accept BTC//USDT/Bank transfer.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
FAQ:
Q: Is there a discount.
Yes, for larger quantity, we always support with better price.
Q2: Can I have free samples
Yes, we can supply the free 10-20g sample except high value products, but the shipping cost be paid by you. Generally USD45 for sample fee.
Q3: How do I pay the sample fee
Paypal,,T/T or just provide your courier's account number, we prefer FEDEX.
Q4: How do you treat quality complaint
If quality problem caused by us after Third Party Test, we will send you free goods for replacement or refund your payment.
Q5:What's your MOQ and lead time
Generally MOQ is 1kg, some low value products, MOQ is 25kg and lead time is within 4-5 workdays upon your payment.
Q6: Which products you can export
We are mainly exporting herbal extracts, amino acids, vitamins, cosmetics and APIs.
Q7: Which documents you can provide
Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your
markets have any special requirements, let us know.