1. A strong scientific research team .
2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products).
3. Rich export experience (with practical experience in exporting to more than 30 countries such as North America, Europe, Middle East, and Southeast Asia).
4. Professional pre-sales and after-sales services (customer first is the core belief of our sales team).
5. Ability to provide value-added services (we can provide a wealth of product solutions to help customers improve competitiveness and production.

6. Safe and fast delivery Most products have a large inventory, so the products can be sent fast after confirming payment, and the tracking number and packaging details will be notified as soon as possible; Large amount of our products are exported to many countries, such as Germany, Brazil, the United States, Spain, the United Kingdom, France, Canada, Mexico, Poland, Russia, Australia, Norway, Finland and so on, with more than 1000 kg per month. We have cooperative agents in these countries. Our customs clearance company will clear your package without customs problems.
7. Rich experience
We are a professional manufacturer of pharmaceutical chemical raw materials. We have focused on this field for many years, and our product is BP / USP / EP / enterprise standard. We guarantee all purity > 99%. High purity and good quality are one of the greatest secrets of our success; You can get the best quality and service from us

Details

kunsui chem (hangzhou) co. limited, established in 2000, dedicated to the development, production and marketing of chemicals. we are a leading manufacturer and supplier of chemicals in china.

manufacturing base: the company has some manufacturing base in zhejiang, jiangsu and shandong provide. these bases focus on production and contract manufacturing.

sales agent: dayangchem are authorized by many chinese chemical manufacturers as universal agency and international area agency. dayangchem has established very good cooperation and business relations with hundreds of chinese qualified manufacturers by long time business intercourse.

strong quality control system: strength of our ethical commitment to quality control and quality assurance systems firmly based on iso standard. qa and qc used in the whole process of raw material control, process control and finished product quality inspection.

third lab test: audit directly and tested by third party like sgs or intertek in any time will be accepted under required.

flexible payment terms: various payment terms such as l/c,d/p,d/a and t/t will be accepted. special notice: dayangchem never require customers to remit payment to a personal account. beware of being cheated.

rich experience in sales: 1000 square meters of office space with independent property rights, sales team of nearly 40 people. our customers throughout the world, especially the world-renowned companies, such as bachem, basf, celanese, corden,dow,evonik, genzyme,henkel, merck,roche,sanofi,solvay.

Usages: 

Bugitinib is a new-generation tyrosine kinase inhibitor with significant efficacy in ALK+ metastatic NSCLC. On August 30, 2016, the US FDA granted bugitinib as a breakthrough therapy for patients who have progressed or cannot tolerate crizotinib, the first-generation ALK+NSCLC treatment, and the rare drug status for ALK+NSCLC treatment. Give priority to listing application review and allow application data to be submitted on a rolling basis. The FDA approved bugitinib on April 28, 2017, under the brand name Alunbrigtm. Bugitinib is a tyrosine kinase receptor (MERTK) inhibitor that can be used in combination with epidermal growth factor receptor (EGFR) inhibitors for cancer treatment. Pharmacological action Bugitinib is an inhibitor of tyrosine kinases at concentrations that can be achieved in vitro and clinically. ROS1 proto-oncogene (C - rosproto - oncogene1), insulin-like growth factor 1 receptor (insulin - likegrowthfactor1receptor, IGF-1R and FMS-like tyrosinekinase 3(FMS-liketyrosine kinase, FLT-3), as well as epidermal growth factor receptor (EGFR) deletion and point mutation have inhibitory activity. In vitro and in vivo, bugitinib inhibited the phosphorylation of ALK itself and mediated the phosphorylation of downstream signaling proteins STAT3, AKT, ERK1/2 and S6. Bugitinib also inhibited the proliferation of cell lines expressing EML4-ALK and NFM-ALK fusion proteins in vitro, and showed dose-dependent effects in inhibiting the growth of EML4-ALK+NSCLC xenografts in mice. In clinical practice, with a concentration of ≤500nmol•L-1, bugitinib can inhibit the survival rate of EML4-ALK cells and 17 mutants in vitro, which are associated with resistance to ALK inhibitors. Including crizotinib and EGFR-Del(E746-A750), ROS1-L2026M, FLT3-F691L and FLT3-D835Y. Bugtinib also showed antitumor activity in vivo against four EML4-ALK mutants, including G1202R and L1196M mutants isolated from plasma in patients with advanced NSCLC after crizotinib treatment. Bugitinib can reduce the load of intracranial implanted ALK with tumor driving cell lines and prolong the survival of mice. Bugitinib is indicated for patients with ALK-positive metastatic NSCLC who cannot tolerate crizotinib treatment or whose disease has progressed. This indication is accelerated based on the rate of tumor response and duration of response, and subsequent approval of the indication may depend on confirmation of further clinical trials and description of clinical benefit. Dose adjustment for adverse reactions, if 90mg is being taken once a day. The first dose can be reduced to 60mg, once a day, and if adverse reactions occur again, the medication will be permanently terminated; If you are taking 180mg, once a day. The first decrement was 120mg once a day, the second decrement was 90mg once a day, and the third decrement was 60mg once a day. The dose should be reduced due to adverse reactions and not subsequently increased at will. If 60mg cannot be tolerated, the dose once a day should be permanently discontinued. Bioactive Brigatinib(AP26113) is a potent and selective ALK inhibitor with IC50=0.6nM; Also a ROS1 inhibitor, IC50=0.9nM. It also inhibits IGF-1R, FLT3, FLT3(D835Y), and EGFR with relatively low potency. Target TargetValueALK(Cell-freeassay)0.37nMROS1(Cell-freeassay)1.9nMFLT3(Cell-freeassay)2.1nMIGF1R(Cell-freeassay)24.9nMEGFR(Cell-Freeassay) In addition to ALK,IGF1R and InsR, brigatinib also effectively inhibited FLT3 and ROS1 with IC50 of 2.1nM and 1.9nM, respectively. At 1μM, brigatinib showed no significant activity against c-Met or Ron. Brigatinib overcomes resistance to EGFR trimutants, an activity dependent on ATP competition that has little effect on wild-type EGFR. The pharmacokinetics of oral administration of Brigatinib in mice were studied in vivo: Cmax=448ng/mL,t1/2=5.8h. In CD rats, after intravenous injection of 3mg/kg, CL=0.46L/(h·kg),t1/2=4.8h,Vss=7.8L/kg; When 10mg/kg is taken orally, Cmax=305ng/mL,tmax=4h,t1/2=3.4h, F%=52. Brigatinib has dose-dependent antitumor activity. In a PC9 triple mutant transplanted tumor model, Brigatinib has a growth-inhibiting effect that, when combined with anti-EGFR antibodies, enhances efficacy in vivo and in vitro.

About Us:

Hebei Kunsui Technology Co., Ltd. specializes in exporting high quality Pharmaceutical raw materials, plant extract, pesticide raw materials  and Chemical raw materials.
Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.

Details

kunsui chem (hangzhou) co. limited, established in 2000, dedicated to the development, production and marketing of chemicals. we are a leading manufacturer and supplier of chemicals in china.

manufacturing base: the company has some manufacturing base in zhejiang, jiangsu and shandong provide. these bases focus on production and contract manufacturing.

sales agent: dayangchem are authorized by many chinese chemical manufacturers as universal agency and international area agency. dayangchem has established very good cooperation and business relations with hundreds of chinese qualified manufacturers by long time business intercourse.

strong quality control system: strength of our ethical commitment to quality control and quality assurance systems firmly based on iso standard. qa and qc used in the whole process of raw material control, process control and finished product quality inspection.

third lab test: audit directly and tested by third party like sgs or intertek in any time will be accepted under required.

flexible payment terms: various payment terms such as l/c,d/p,d/a and t/t will be accepted. special notice: dayangchem never require customers to remit payment to a personal account. beware of being cheated.

rich experience in sales: 1000 square meters of office space with independent property rights, sales team of nearly 40 people. our customers throughout the world, especially the world-renowned companies, such as bachem, basf, celanese, corden,dow,evonik, genzyme,henkel, merck,roche,sanofi,solvay.

Packing & Shipping:

Packing&Delivery:
Packing and Storage: Packed in double plastic bags inside, outside with 25kg Fiber Drum.
Drum Size: 40cm*40cm*50mm, 25KG/drum Nt.;27.5Kg/drum.Gt. Store in a well-closed container away from moisture.
Shelf Life: 2 years if sealed and store away from direct sun light.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Delivery time: Around 3 workdays after your payment.
Payments:We accept BTC//USDT/Bank transfer.

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 
  2. Shipping details & shipping documents will be provided and sent by email. 
  3. We keep tracking the shippment until clients well received. 
  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

FAQ:

Q: Is there a discount.

Yes, for larger quantity, we always support with better price.

Q2: Can I have free samples

Yes, we can supply the free 10-20g sample except high value products, but the shipping cost be paid by you. Generally USD45 for sample fee.

Q3: How do I pay the sample fee

Paypal,,T/T or just provide your courier's account number, we prefer FEDEX.

Q4: How do you treat quality complaint

If quality problem caused by us after Third Party Test, we will send you free goods for replacement or refund your payment.

Q5:What's your MOQ and lead time

Generally MOQ is 1kg, some low value products, MOQ is 25kg and lead time is within 4-5 workdays upon your payment.

Q6: Which products you can export

We are mainly exporting herbal extracts, amino acids, vitamins, cosmetics and APIs.

Q7: Which documents you can provide

Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your
markets have any special requirements, let us know.